Adipose tissue-derived stem cells(ADSCs)
In Japan, according to the Act on Securing the Safety of Regenerative Medicine, etc., regenerative medicine is available after approval by a specially authorized committee for regenerative medicine, etc., and acceptance of the treatment plan by the Ministry of Health, Labour and Welfare.
At the hospital, the following regenerative treatments have been accepted by the Ministry of Health, Labor and Welfare.
We will continue to do our best to provide the best regenerative medicine to patients suffering from intractable diseases.
What is regenerative medicine?
 Regenerative medicine is a treatment that cures diseases by cultivating our own stem cells and then returning them to our bodies, rather than using drugs, which are "chemical substances”. It is a treatment that repairs tissues and organs by making the most of our innate regenerative abilities.

There are three types of stem cells as follows;
1) Human somatic stem cells
2) Human embryonic stem cells (ES cells) (derived from fertilized eggs)
3) Human induced pluripotent stem cells (iPS cells)
What are human somatic stem cells?
Since it was reported that mesenchymal stem cells (stem cells) exist in adipose tissue, therapeutic research has been conducted on adipose tissue-derived stem cells (ADSCs), which are minimally invasive and relatively easy to collect.
Characteristics of mesenchymal stem cells (Stem Cells)
  1. They have the property of gathering in the damaged tissue, which is called homing effect. For example, when administered intravenously to a patient with a brain disease, they gathers at the site of the brain lesion.
  2. They secrete various growth factors and cytokines (immunomodulators).
Growth factors (GFs) produced from human adipose tissue-derived stem cells.
1VEGF(Vascular Endothelial Growth Factor)
2EGF(Epidermal Growth Factor)
3HGF(Hepatocyte Growth Factor)
4KGF(Keratinocyte Growth Factor)
5bFGF(basic Fibroblast Growth Factor)
6aFGF(acidic Fibroblast Growth Factor)
7IGF-1(Insulin like Growth Factor)
8PDGF(Platelet Derived Growth Factor)
10GM-CSF(Granulocyte Macrophage Colony-Stimulating factor)
11G-CSF(Granulocyte Colony-Stimulating factor)
12aFF(Anti-fibrosis Factor)
13NGF(Never Growth Factor)
Diseases for which regenerative medicine has been approved at our hospital.
Refractory neurodegenerative disease
Amyotrophic Lateral Sclerosis〈ALS〉
Spinocerebellar Degeneration〈SCD〉
Lewy body disease〈DLB〉
Progressive Supranuclear Palsy〈PSP〉
Repeated infusion of autologous adipose tissue-derived stem cells
再生医療を受ける者に対する説明文書及び同意書文書の様式  資料1 資料2
Refractory respiratory interstitial disease
Pulmonary emphysema<COPDを含む>
Idiopathic Pulmonary Fibrosis<IPF>
Interstitial Pneumonia
Repeated infusion of autologous adipose tissue-derived stem cells
再生医療を受ける者に対する説明文書及び同意書文書の様式  資料1 資料2
Alzheimer's disease
Alzheimer's disease
Repeated infusion of autologous adipose tissue-derived stem cells
再生医療を受ける者に対する説明文書及び同意書文書の様式  資料1 資料2
Parkinson's disease
Parkinson's disease
Repeated infusion of autologous adipose tissue-derived stem cells
再生医療を受ける者に対する説明文書及び同意書文書の様式  資料1 資料2
Procedure for Treatment
1 Blood test
A blood test, including viral and bacterial tests, will be conducted on the first visit.
Please note that if the results of the viral and bacterial tests are positive, please be advised that you will not be able to receive the relevant treatment.
2 Harvesting of adipose tissue
The abdomen, buttocks, or any other area where adipose tissue can be harvested will be determined after consultation with the doctor in charge of the procedure, and the adipose tissue will be harvested under local anesthesia.
The surgery takes about one hour.
Blood for stem cell culture will also be taken during the surgery.
3 Culture of adipose tissue-derived stem cells
It takes about two months to culture.
We will inform you of the date and time when it is ready to be administered.
4 Administration of adipose tissue-derived stem cells
After the initial infusion, the administration will be done every 2 to 4 weeks.
The number of doses and intervals will be determined by your doctor based on your medical condition.
We comply with the Act on Securing the Safety of Regenerative Medicine and Other Related Matters.

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